Ralf Kubitz Selected Research

progressive familial intrahepatic 1 Cholestasis

5/2018	Phenotypic spectrum and diagnostic pitfalls of ABCB4 deficiency depending on age of onset.
10/2017	Post-transplant Recurrent Bile Salt Export Pump Disease: A Form of Antibody-mediated Graft Dysfunction and Utilization of C4d.
2/2016	Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency.
6/2015	Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis.
5/2015	Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2.
9/2012	The histidine-loop is essential for transport activity of human MDR3. A novel mutation of MDR3 in a patient with progressive familial intrahepatic cholestasis type 3.
8/2009	De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis.
10/2005	Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.
5/2005	Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis.

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Ralf Kubitz Research Topics

Disease

9	progressive familial intrahepatic 1 Cholestasis 05/2018 - 05/2005
8	Cholestasis 06/2015 - 05/2003
6	Liver Diseases (Liver Disease) 01/2021 - 01/2011
4	Intrahepatic Cholestasis 12/2017 - 02/2006
4	Pruritus (Itching) 08/2017 - 08/2006
3	Liver Cirrhosis (Hepatic Cirrhosis) 06/2015 - 01/2005
3	Fibrosis (Cirrhosis) 11/2013 - 10/2008
2	Intrahepatic Cholestasis of Pregnancy 05/2018 - 08/2006
2	Anemia 01/2016 - 01/2015
2	End Stage Liver Disease 06/2015 - 06/2014
2	Infections 07/2014 - 04/2014
2	Hepatocellular Carcinoma (Hepatoma) 04/2014 - 08/2004
2	Hepatitis B 04/2014 - 11/2013
1	Biliary Atresia 05/2018
1	Alagille Syndrome (Alagille-Watson Syndrome) 05/2018
1	Cholelithiasis 05/2018
1	Hypersensitivity (Allergy) 10/2017
1	Jaundice (Icterus) 08/2017
1	Hyperplasia 03/2016
1	Hemorrhage 06/2015
1	Colitis 05/2015
1	Bronchial Spasm 02/2015
1	Hypotension (Low Blood Pressure) 02/2015
1	Cysts 02/2015
1	Anaphylaxis (Anaphylactic Shock) 02/2015
1	Shock 02/2015
1	Hyperbilirubinemia 01/2015
1	Chemical and Drug Induced Liver Injury 06/2014
1	Chronic Hepatitis C 01/2011
1	Disease Progression 01/2011
1	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 01/2011
1	Hepatitis C 01/2011
1	Gallstones (Gallstone) 09/2009
1	Liver Failure 08/2009
1	Neoplasms (Cancer) 08/2004
1	Body Weight (Weight, Body) 05/2003

Drug/Important Bio-Agent (IBA)

12	Bile Acids and Salts (Bile Acids)IBA 08/2017 - 05/2005
11	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 12/2017 - 05/2003
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2006
3	Taurocholic Acid (Sodium Taurocholate)IBA 04/2014 - 05/2003
2	Phospholipids (Phosphatides)FDA LinkGeneric 05/2018 - 10/2008
2	Adenosine Triphosphate (ATP)IBA 05/2018 - 08/2009
2	multidrug resistance protein 3IBA 12/2017 - 06/2015
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 06/2015 - 08/2009
2	Transaminases (Aminotransferases)IBA 01/2011 - 08/2006
2	Carrier Proteins (Binding Protein)IBA 01/2011 - 05/2005
1	Phosphatidylcholines (Phosphatidylcholine)IBA 05/2018
1	Adenosine Triphosphatases (ATPase)IBA 12/2017
1	Blocking AntibodiesIBA 10/2017
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2017
1	P-type ATPasesIBA 06/2015
1	SteroidsIBA 05/2015
1	BilirubinIBA 01/2015
1	Small Interfering RNA (siRNA)IBA 04/2014
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 04/2014
1	Peptides (Polypeptides)IBA 04/2014
1	myrcludex-BIBA 04/2014
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 09/2012
1	Ribavirin (Virazole)FDA LinkGeneric 01/2011
1	Chenodeoxycholic Acid (Chenix)FDA Link 01/2011
1	InterferonsIBA 01/2011
1	Cholic AcidIBA 01/2011
1	Alanine Transaminase (SGPT)IBA 01/2011
1	Antiviral Agents (Antivirals)IBA 01/2011
1	Messenger RNA (mRNA)IBA 09/2009
1	AutoantibodiesIBA 08/2009
1	AntibodiesIBA 08/2009
1	CytokinesIBA 07/2008
1	UbiquitinIBA 10/2005
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2004
1	OccludinIBA 08/2004
1	Protein Kinase CIBA 03/2004
1	Protein Isoforms (Isoforms)IBA 03/2004
1	p38 Mitogen-Activated Protein KinasesIBA 02/2004
1	ATP-Binding Cassette Sub-Family B Member 4IBA 05/2003
1	LipopolysaccharidesIBA 05/2003
1	EndotoxinsIBA 05/2003
1	Taurine FDA Link 05/2003
1	Sulfobromophthalein (Sulfobromophthalein Sodium)IBA 05/2003

Therapy/Procedure

5	Liver Transplantation 10/2017 - 01/2005
3	Ligation 03/2016 - 07/2008
3	Therapeutics 06/2015 - 08/2004
1	Surgical Portasystemic Shunt (Portosystemic Shunt) 06/2015
1	Transjugular Intrahepatic Portasystemic Shunt 06/2015
1	Punctures 02/2015